加拿大Cedarlane human高密度脂蛋白HDL 10mg

Introduction; HDL is a complex of lipids and proteins in approximately equal amounts that functions as a transporte

of cholesterol in the blood. HDL is the smallest of the lipoprotein particles; it's the densest because it contains th

highest proportion of protein. The liver synthesizes these lipoproteins as complexes of apolipoproteins an

phospholipid, which bear a resemblance to cholesterol-free flattened spherical lipoprotein particles. They pick u

cholesterol; carry it internally, from cells by interaction with the ATP Binding Cassette Transporter Al. Lecithin

cholesterol acyltransferase (plasma enzyme) converts the free cholesterol into cholestery1 ester (a more hydrophobic

form of cholesterol) which is then sequestered into the core of the lipoprotein particle ultimately making the newly

synthesized HDL spherical. They increase in size as they pass through the bloodstream and integrate more cholesterol

and phospholipid molecules from cells and other lipoproteins, for instance by the interaction with the ABCGI

transporter and the phospholipid transport protein. HDL transports their cholesterol generally to the liver or

steroidogenic organs such as adrenals, ovary and testes by direct and indirect pathways. The release of HDL

cholesterol to adrenals, ovaries and testes is important for the synthesis of steroid hormones. Since the triglycerides

are not stable in HDL, they're degraded by hepatic lipase in order that finally small HDL particles are left which

resume the uptake of cholesterol from cells. The cholesterol supplied to the liver is excreted into the bile and

consequently intestine either directly or indirectly after conversion into bile acids. High levels of HDL are associated

with a decreased risk of atherosclerosis and coronary heart disease.